Acute oral toxicity (rat): practically non-toxic
(Hazleton Wisconsin; mar 28, 1991; hwi 10102633)
4-week oral gavage toxicity study (rats):.
Based on the results of this study, the no-observable-effect level for pf-5060 in male and female rats was greater than 2,000 mg/kg.
(Hazleton Wisconsin; feb 05, 1992; hwi 6329-102).
Primary dermal irritation (rabbit): non-irritating.
(Hazleton Wisconsin; apr 04, 1991; hwi 10102634)
Primary ocular irritation (rabbit): non-irritating.
(Hazleton Wisconsin; apr 04, 1991; hwi 10102635)
Acute inhalation: the data suggest that the 1-hour acute lc50 is greater than 5,260 milligrams per liter. the acute toxicity of the vapors is very low.
(Industrial Bio-test Laboratories, inc.; jul 19, 1976; 3m t-1497)
Sub-chronic inhalation: some differences were observed between the test Animals and controls in some blood chemistry parameters and in hematologic values (females only). All blood study results are considered to be within a biologically acceptable range. the significance of these findings is not known at this time. a review of these findings by the 3m medical department exposure guideline committee led the committee to conclude that these findings are biologically unimportant because the exposures were high and for an extended period.
(University of California at San Francisco; dec 01, 1977; 3m t-1690)
Two-week repeat dose preliminary inhalation toxicity study in rats rats were exposed to 50,000 parts per million of pf-5060 for six hours a day, five days a week for two weeks in a 750 liter exposure chamber (whole body exposure). No effects were considered to be of toxicological significance.
(Huntington Research Centre; jun 08, 1992; min 56/911538)
90-day inhalation toxicity study (rat): in summary, no significant effects were found in the 90-day inhalation toxicity study with perfluorohexane. The no adverse effect level for the study is 49,821 ppm.
(Huntington Research Centre; nov 02, 1992; min 59/920819)
Cardiac sensitization (dog): not a cardiac sensitizer.
(Huntington Research Centre; dec 02, 1992; min 62a/921210)
Salmonella/mammalian-microsome reverse mutation assay: no cytotoxicity. The product cannot be adequately tested using the salmonella mutation assay.
(Hazleton Washington; oct 22, 1991; hla 12615-0-401)