Major HFO Molecules

Designation Complete name Formula Cas number GWP (1)

AR4 (2)

GWP (1)
AR5 unless stated
Atmospheric liftime(3)unless stated Ozone Deplating Substance (ODS) Main Potential Applications
 HCFO 1224ydZ  2,3,3,3 Tetrafluoro-1-chloroprop-1 ene CF3-CF=CHCl  111512-60-8 na <1 (4)ODP=0.00012 21 days (4) No, a VSLS (5)
 HBFO 1233xfB  2-bromo-3,3,3-trifluoropropene
CF3CBr=CH2  1514-82-5 na 0.26 7 days (4) No, a VSLS (5)
HCFO 1233zdE Trans 1-Chloro-3,3,3-
Trans-CHCl=CHCF3 2730-43-0 4.5 1 26 days No, a VSL (5)
HFO 1234yf 2,3,3,3- tetrafluoroprop-1-ene CF3CF=CH2 754-12-1 4 (6) <1 10.5 days No
HFO 1234zeE Trans-1,3,3,3-tetrafluoroprop-1-ene Trans- CF3CH=CFH 29118-24-9 7(6) <1 16.4 days No
  • Refrigerant for chillers, refrigeration
  • Blend component for HFC-HFO blends
  • Aerosol propellant
  • Blowing agent for insultation foams
HFO 1336mzz(E) Trans-1,1,1,4,4,4-hexafluorobut-2-ene Trans- CF3CH=CHCF3 66711-86-2 7(7) <1 67 days (7) No
HFO 1336mzz(Z) 1,1,1,4,4,4-hexafluorobut-2-ene cis-
692-49-9 9 2 (7&3) 22 days (8&3) No


See also: Hydrofluoroolefins (HFOs)


1) See Selecting and using GWP values
2) IPCC Fourth Assessment Report GWP values
3)  IPCC Working Group I – The Physical Science Basis – Chap.8 Annex 8.A.1
4) Measured by the National Institute of Advanced Industrial Science and Technology (AIST), Japan, GWP calculated according to the IPCC AR5 method
5) Very short lived substances (VSLS) have chemical lifetimes comparable with tropospheric transport time scales, with the result that the amount of the substance in the atmosphere depends on where and when (time of year) it is released. In practice, this happens for species with atmospheric lifetimes of a few months or less. From a regulatory point of view this means that VSLS cannot be included in the normal categories of the Montreal Protocol; not only is their contribution to ozone depletion very low but it is highly variable between countries and regions. For more detail see Learn About HCFO-1224yd(Z), HCFO-1233zdE, HBFO-1233xfB, Stratospheric Ozone and Climate Change
6) GWP according to the Report of the 2010 Assessment of the Scientific Assessment Panel (SAP) of the Montreal Protocol, Tables 1-11, citing two peer-reviewed scientific references
7) Athmospheric chemistr of Z-and E-CF3CHQCHCF3, Freja F. Østerstrøm, Simone Thirstrup Andersen, Theis I. Sølling, Ole John Nielsena and Mads P. Sulbaek Andersen, Phys. Chem. Chem. Phys., 201719, 735-750,
8) M.Baasandorj, A.R. Ravishankara and J.B. Burkholder, J. Phys. Chem. A, 2011, 115, 10539-10510549.