Designation and Safety Classification of Refrigerants

The basis of the designation of the refrigerants fluids is based on a numbering system

Pure Fluorocarbons (HFC) refrigerants and their blends

The refrigerants are numbered with an R-, followed by the HFC-number, given by the rules of the fluorocarbons numbering system. Isomers are identified with lower cases (ex R 134a). HFC refrigerant blends (i.e. mixtures of pure refrigerants), are numbered after the internationally accepted ASHRAE nomenclature. Blends having the same pure components but with different compositions are identified with upper cases (ex R 404A). Refrigerants having the form R-4xxx are zeotropic blends of two or more refrigerants, while those with the form R-5xxx are azeotropes. The numbers are in chronological order of the refrigerant’s approval by ASHRAE. For the GWP of Refrigerants go to “Learn About – Climate Change, Global Warming & HFCs

Designation and safety classification of refrigerants

 

Type Profile Application GWP
F-Gas AR4
R-32 Air-conditioning     675
R-134a Replace R-12 in most applications. Good performance in medium temperature applications ; household refrigerators; car air conditioning systems; heat pumps; chillers; transport refrigeration; commercial cooling.  1,430
R-245fa Replacement of R-123. Heat pumps, Organic Rankine Cycle.  1,030
R-404A Near azeotropic refrigerant containing R-125, R-143a and R-134a (44/52/4% by weight). Cold-storage cells; supermarket display cases; ice machines; replacement for R-502 in transport refrigeration; retrofit of existing R-502-installations R-407A Zeotropic refrigerant containing R-32, R-125 and R-134a (20/40/40 weight-%). Close replacement of R-22 in commercial refrigeration applications. Possible replacement for R-404A in supermarket chill and low temperature systems.  3,922
R-407A Zeotropic
Replacement for retrofit gas
containing  R-32/125/134a(20.0/40.0/40.0% Mass)
Medium and low temperature commercial refrigeration  2,107
R-407B Zeotropic refrigerant containing R-32, R-125 and R-134a (10.0/70.0/20.0 Mass % Refrigerant – Medium and Low temperature – Commercial refrigeration.  2,804
R-407C Zeotropic refrigerant containing R-32, R-125 and R-134a (23/25/52 weight-%). New air-conditioning units or replacement for R-22 in existing installations; heat-pumps; industrial and commercial cooling. R-407F Zeotropic refrigerant containing R-32, R-125 and R-134a (30/30/40 weight-%). Close replacement of R-22 in commercial refrigeration applications. Possible replacement for R-404A in supermarket medium and low temperature systems.  1,774
 R-407D Zeotropic refrigerant containing R-32, R-125 and R_134a (15.0/15.0/70.0 % Mass). Transport refrigeration.  1,627
 R-407E Zeotropic refrigerant containing R-32, R-125 and R_134a (25.0/15.0/60.0 % Mass). Close replacement of R-22. Air-conditioning units. 1,552
 R-407F Zeotropic refrigerant containing R-32, R-125 and R_134a (30/30/40 weight-%). Medium and low temperature commercial refrigeration.  1,825
 R-407G Zeotropic refrigerant containing R-32, R-125 and R_134a (2.5/2.5/95.0% Mass). Similar to R-134a with higher capacity. 1,463
 R-407H Zeotropic refrigerant containing R-32, R-125 and R_134a (32.5/15.0/52.5% Mass). Medium and low temperature commercial refrigeration. 1,495
R-410A Near azeotropic refrigerant containing R-32 and R-125 (50/50 by weight). Medium and low temperature commercial refrigeration.  2,088
R-410B Near azeotropic refrigerant containing R-32 and R-125 (45.0/55.0 mass). Similar properties to R-410A but R-410A dominates commercially.  2,229
R-413A Contains R-218/R-134a/R600A (9.0/88.0/3.0%). Retrofit refrigerant replacement for R-12 in some air-conditioning systems and medium and high temperature refrigeration.  2,053
R-417A Contains R-125, R-134A and R-600 (46.6/50.0/3.4% mass). R-22 substitute.  2,346
R-417B Contains R-125, R-134a and R-600 (79/18.25/2.75 weight-%). Replacement for R-22; F-Gas Regulation use restrictions (GWP >2500).  3,027
R-417C Contains R-125, R-134a and R-600 (19.5/78.8/1.7 % mass). R-22 substitute.  1,809
R-419A Contains R-125, R-134a/E170 (77.0/19.0/4.0 % mass). Replacement for R-22; F-Gas Regulation use restrictions (GWP >2500).  2,967
R-419B Contains R-125, R-134a/E170 (48.5/48.0/3.5 % mass). Replacement for R-22.  2,384
R-421A Contains R-125, R-134a (58.0/42.0 % mass). Replacement for R-22; F-Gas Regulation use restrictions (GWP >2500).  2,631
R-421B Contains R-125, R-134a (85.0/15.0 % mass). Replacement for R-22; F-Gas Regulation use restrictions (GWP >2500).  2,631
R-422A Contains R-125, R-134a and R-600a (85.1/11.5/3.4 weight-%). Similar properties to R-404A; F-Gas Regulation use restrictions (GWP >2500).  3,143
R-422B Contains R-125, R-134a and R-600a (55.0/42.0/3.0 weight-%). Replacement for R-22; F-Gas Regulation use restrictions (GWP >2500).  2,526
R-422C Contains R-125, R-134a and R-600a (82.0/15.0/3.0 weight-%). Replacement for R-22 in low/medium temperature refrigeration. F-Gas Regulation use restrictions (GWP >2500).  3,085
R-422D Contains R-125, R-134a and R-600a (65.1/31.5/3.4 weight-%). Replacement for R-22; F-Gas Regulation use restrictions (GWP >2500).  2,729
R-422E Contains R-125, R-134a and R-600a (58.0/39.3/2.7 weight-%). Replacement for R-22; F-Gas Regulation use restrictions (GWP >2500)  2,592
R-423A Contains R-134a and R227ea (52.5/47.5 weight-%). Non-flammable retrofit replacement for R12 in centrifugal chillers.  2,280
R-424A Contains R125/134a, 600a/600/601A (50.5/47.0/0.9/1.0/0.6 weight-%). Non-flammable retrofit replacement for R-22 in medium and high temperature air-conditioning and refrigeration systems  2,440
R-425A Contains R32/134a, 227ea (18.5/69.5/12 weight-%). Non-flammable retrofit replacement for R-22 in medium and high temperature air-conditioning and refrigeration systems  1,505
R-426A Contains R125, 134a, 600, 601a (5.1/93.0/1.3/0.6 weight-%). Non-flammable retrofit replacement for R-22 in medium and high temperature air-conditioning and refrigeration systems  1,508
R-427A Contains R-32, R-125, R-134a and R-143a (15.0/25.0/50.0 weight-%). R-22 subsitute.  2,138
R-428A Contains R-125, R-143a, R-290, R-600a (77.5/20.0/0.6/1.9 weight-%). Non-flammable replacement for R-502 and R-22 in low temperature industrial refrigeration. F-Gas Regulation use restrictions (GWP >2500).  3,607
R-429A Contains R-E170/R152a, R600a (60.0/10.0/0.6/30.0 weight-%). Highly flammable alternative to R-134a for small hermetic systems.  13
R-430A Contains R152a, R600a (76.0/24.0 weight-%). Highly flammable alternative to R-134a for small hermetic systems.  95
R-431A Contains R290, R152a, (71.0/29.0 weight-%). Highly flammable alternative to R-22 for air-conditioning systems and heat pumps.  38
R-434A Contains R125/134a. Retrofit replacement for R-22 in medium and high temperature refrigeration. F-Gas Regulation use restrictions (GWP >2500)  3,245
R-435A Contains E170/ 152A. (80.0/20.0 weight %). Highly flammable alternative to R-134a for small hermetic systems.  25
R-437A Contains R125/ 134A/600/601. (19.5/78.5/1.4/0.6 weight %). Highly flammable alternative to R-134a for small hermetic systems.  1,805
R-438A Contains R32, R125, R134A, R600, R601a. (8.5/45.0/44.2/1.7,0.6 weight %). Non-flammable replacement for R-22.  2.265
R-439A Contains R32, R125, R134A, R600. (50.0/47.0/3.0 weight %). Retrofit replacement for R-22  1,983
R-440A Contains R290, R134A. (0.6/1.6/97.8 weight %). Retrofit replacement for R-134a  144
R-442A Contains R32, R125, R134A, R152a, R227ea. (31.0/31.0/30.0/3.0/5.0 weight %). Retrofit replacement for R-134a  1,888
R-444A Contains R32, R152a, R1234ze(E). (12.0/5.0/83.0. weight %). Replacement for R-134a in medium temperature commercial refrigeration.  91
R-444B Zeotropic refrigerant containing R-32, R-152a and R-1234ze (41.5/10/48.5 weight %) Replacement for R-22/R-407C.  294
R-445A Zeotropic refrigerant containing R-744, R-134a,R1234ze(E) (6.0/9.0/85.0 weight %) Replacement for R-134a in mobile air-conditioning.  132
R-446A Zeotropic refrigerant containing R-32,, R-1234ze(E),R-600
(68.0/29.0/3.0) weight %)
Replacement for R-410A in stationary air-conditioners.  460
R-447A Zeotropic refrigerant containing R-32, R-125, 1234ze(E),  (68.0/3.5/28.5) weight %) Replacement for R-410A in stationary air-conditioners.  583
R-447B Zeotropic refrigerant containing R-32, R-125, 1234ze(E),  (68.0/8.0/24.0) weight %) Replacement for R-410A in stationary air-conditioners.  740
R-448A Zeotropic refrigerant containing R-32/R-125/R-134a/R-1234yf/R-1234azeE (26/26/21/20/7 weight %) Non-flammable replacement for 404A in low and medium temperature commercial and transport refrigeration.  1,387
R-449A  Zeotropic refrigerant containing R-32/R-125/R-134a/R-1234yf/(24.3/24.7/25.7/25.3 weight %) Non-flammable replacement for 404A in low and medium temperature commercial and transport refrigeration.  1,398
R-449B  Zeotropic refrigerant containing R-32/R-125/R-134a/HFO-1234yf/(25.2/24.3/27.3/23.2 weight%) Non-flammable replacement for 404A in low and medium temperature commercial and transport refrigeration.  1,413
R-449C  Zeotropic refrigerant containing R-32/R-125/R-134a/HFO-1234yf/(25.2/24.3/27.3/23.2 weight%) Non-flammable replacement for 404A.  1,252
R-450A  Near azeotropic refrigerant containing R-134a and R-1234ze(E) (42.0/58.0 weight %) Non-flammable replacement for R-134a in medium temperature commercial refrigeration    603
R-451A  Near azeotropic refrigerant containing R-134a and R-1234ze(E) (89.8/10.2 weight %) Replacement for R-134a.    152
R-451B  Near azeotropic refrigerant containing R-134a and R-1234ze(E) (88.8/11.2 weight %) Replacement for R-134a    166
R-452A Zeotropic refrigerant containing R-32, R-125 and R-123yf (11/59/30 weight %) Non-flammable replacement for 404A in low and medium temperature commercial and transport refrigeration.  2,141
R-452B Zeotropic refrigerant containing R-32, R-125 and R-123yf (67/7/26 weight %) Replacement for R-410A in chillers    699
R-452C Zeotropic refrigerant containing R-32, R-125 and R-123yf (12.5/61.0/26.5 weight %) Non-flammable replacement for 404A in low and medium temperature commercial refrigeration.    2,221
R-453A Zeotropic refrigerant containing R-32, R-125, R134a, 227ea/600/601a (20.0/20.0/53.8/5.0/0.6/0.6 weight %) Non-flammable retrofit replacement for R-22 for air-conditioning and refrigeration applications.    1,765
R-454A  R-32/1234yf (35.0/65.0 weight%) Replacement for 404A in low and medium temperature commercial refrigeration.    241
R-454B  Zeotropic refrigerant containing R-32 and R-1234yf (68.9/31.1 weight %) Replacement for R-410A.    467
R-454C a blend of R1234yf (78.5%) and R32 (21.5/78.5 %) Replacement for 404A in low and medium temperature commercial refrigeration (hermetic units).    151
R-455A Zeotropic refrigerant containing R-1234yf, R-32 and R-744 (CO2)(75.5/21.5/21.5/3 weight %) Replacement for 404A in low and medium temperature commercial refrigeration (hermetic units).    150
R-456A Zeotropic refrigerant containing R-32, 134a and 1234ze(E) (6.0/45.0.5/49.0 weight %) Non-flammable replacement for R-134a in medium temperature commercial refrigeration.    686
R-457A Zeotropic refrigerant containing R-32, 1234yf, 152a (18.0/70.0/12.0 weight %) Replacement for 404A in low and medium temperature commercial refrigeration.    141
R-458A Zeotropic refrigerant containing R-32, 125, 134a, 227ea, 236fa (20.5/4.0/61.4, 13.5, 0.6) weight %) Non-flammable replacement for R-22.    1,650
R-459A Zeotropic refrigerant containing R-32, 1234yf(E), 1234ze(E) (68.0/26.0/6.0) weight %) Replacement for R-410A.    461
R-459B Zeotropic refrigerant containing R-32, 1234yf(E), 1234ze(E) (21.0/69.0/10.0) weight %) Replacement for 404A in low and medium temperature commercial refrigeration.    147
R-460A Zeotropic refrigerant containing R-32, 125, 134a, 1234ze(E)(12.5/52.0/14.0/22.0 weight %) Non-flammable replacement for 404A in low and medium temperature commercial refrigeration.    2,102
R-460B Zeotropic refrigerant containing R-32, 125, 134a, 1234ze(E)(28.0/25.0/20.0/27.0 weight %) Non-flammable replacement for 404A in low and medium temperature commercial refrigeration.    1351
R-460C Zeotropic refrigerant containing R-32, 125, 134a, 1234ze(E)(2.5/46.0./49.0 weight %) Non-flammable replacement for R-134a.    764
R-461A Zeotropic refrigerant containing R-125, 134a/143a, 227ea, 600a (55.5/5.0/3.0 weight %)    2,767
R-462A Zeotropic refrigerant containing R-32, 125, 143a, 134a, 600a (9.0/42.0/2.0/44.03.0 weight %)    2,249
R-463A Zeotropic refrigerant containing R-744, 32, 125, 134a, 1234yf (6/36/30/14 weight %)    1494
R-464A Zeotropic refrigerant containing R-32, 125, 1234ze(E) 227ea (27/27/40/6 weight %) Non-flammable replacement for R-404A.    1322
R-465A Zeotropic refrigerant containing R-32, 290, 1234yf(E) (21/7.9/71.1 weight %)    147
R-507A Azeotropic refrigerant containing R-125 and R-143a (50/50% by weight) Medium and low temperature commercial refrigeration;F-Gas Regulation use restrictions.  2,465
R-508A Azeotropic refrigerant containing R-23, 116 (39.0/61.0 by weight) Very low temperature refrigeration.  13,214
R-508B Azeotropic refrigerant containing R-23, 116 (46.0/54.0 by weight) Very low temperature refrigeration.  13,396
R-512A Azeotropic refrigerant containing R-134a, 152a (5.0/95.0 by weight) Replacement for R-134a.    189
R-513B Azeotropic refrigerant containing HFO-1234yf and R-134a (58.5/41.5% by weight) Non-flammable replacement for R-134a in medium temperature commercial refrigeration and chillers.    598
R-513A Azeotropic refrigerant containing HFO-1234yf and R-134a (56.0/44.0% by weight) R-134a an R-410A alternative for chillers.    633
R-514A A blend of HFO 1336mzz(Z) (74.7%) with R-1130E (trans-1,2-dichloroethene) (25.3%) Proposed as drop-in substitute to HCFC-123.       2
R-515A  HFO 1234ze (E)227ea 88.0/12.0%) Non-flammable replacement for R-134a, proposed for flooded chillers.     390
R-516A  HFO 1234yf, 134a/152a (77.5/8.5/14.0%) Replacement for R-134a in medium temperature commercial refrigeration.     144
HFO-1234yf Midly flammable replacement for R-134a Mobile air-conditioning, plug in appliances.       4
HFO-1233zdE Non-flammable, low pressure refrigerant. Alternative to R-123 centrifugal chillers, Organic Rankine Cycle: high temperature heat pumps.
Aerosol Propellants, refrigeration and air-conditioning, insulating foams.
      5
HFO-1234zeE  Midly flammable replacement for R-134a (non-flammable replacement for R-134a (non-flammable for handling and storage) R-134a alternative medium temperature applications like water-cooled chillers (supermarkets and commercial buildings), heat pumps, fridges, vending machines, beverage dispenses, air dryers, CO2 cascade supermarket systems, etc.
Insulating foams, precision solvents, chillers.
      7
HFO-1336mzzZ  Non flammable Chillers.
Insulating foams.
     9

Organic compounds are numbered with the same system as Fluorocarbons.

 

Example :

Propane C3H8 (R-290)
Nb of C atoms is X = 3
Nb of H atoms is Y = 8
Nb of F atoms is Z = 0
Substract 90 from 380 = 290

Inorganic compounds shall be assigned a number in the 700 series, identification numbers are formed by adding the relative molecular mass of components to 700.

 

Example :

R717 = ammonia (molecular mass 17)
R718 = water (molecular mass 18)
R744 = CO2 (molecular mass 44)

Safety classification of refrigerants

The safety classification consists of two alphanumeric characters (e.g. A2); the capital letter corresponds to toxicity and the digit to flammability.

Toxicity classification

Refrigerants are divided into two groups according to toxicity:

 

  • Class A signifies refrigerants for which toxicity has not been identified at concentrations less than or equal to 400 ppm
  • Class B signifies refrigerants for which there is evidence of toxicity at concentrations below 400 ppm
Flammability classification

Refrigerants are divided into three groups according to flammability:

 

  • Class 1 indicates refrigerants that do not show flame propagation when tested in air at 21°C and 101 kPa
  • Class 2 indicates refrigerants having a lower flammability limit of more than 0.10 kg/m3 at 21°C and 101 kPa and a heat of combustion of less than 19 kJ/kg
  • Class 3 indicates refrigerants that are highly flammable as defined by a lower flammability limit of less than or equal to 0.10 kg/m3 at 21°C and 101 kPa or a heat of combustion greater than or equal to 19 kJ/kg
Mixtures

Mixtures, whether zeotropic or azeotropic, with flammability and/or toxicity characteristics which may change as the composition changes during fractionation, shall be assigned a safety group classification based on the worst case of fractionation.

 

Example:

R404A is classified A1

Classification of main refrigerants
Refrigerant Number Name Composition or chemical formula
(mass percentage)
Safety classification
Inorganic Compound
R-717 ammonia NH3 B2
R-718 water H2O A1
R-744 carbon dioxide CO2 A1
Organic Compound
Hydrocarbons
R-290 propane CH3CH2CH3 A3
R-600 butane CH3CH2 CH2CH3 A3
R-600a isobutane CH(CH3)2CH3 A3
R-1270 propylene CH3CH=CH2 A3
Hydrofluorocarbons (HFCs)
R-32 difluoromethane CH2F2 A2
R-125 pentafluoroethane CHF2CF3 A1
R-134a 1,1,1,2-tetrafluoroethane CH2FCF3 A1
R-143a 1,1,1-trifluoroethane CH3CF3 A2
R-152a 1,1-difluoroethane CH3CHF2 A2
Azeotropic mixtures
R-502 R22/R115 (48.8/51.2) A1
R-507 R125/R143a (50/50) A1
Zeotropic mixtures
R-404A R125/R143a/R134a (44/52/4) A1
R-407C R32/R125/R134a (23/25/52) A1
R-410A R32/R125 (50/50) A1