EFCTC: Toxicological Impact of Fluorocarbons


Risk assessments of the most important fluorocarbons are carried out from various initiatives such as the US Challenge program (EPA), the EU Priority list ( under Existing Chemicals program), or by the OECD ( under HPV Chemicals programme)

ICCA: International Council of Chemical Associations (of which CEFIC is the European member), has launched a Global Initiative on High Production Volume (HPV) Chemicals in 1998 and has joined the OECD Program.
The objective of this initiative is to provide globally harmonized, internationally agreed data sets and initial hazard assessments for around 1,000 HPV substances, under the form of:

  • a Screening Information Data Set Dossier (SIDS Dossier)
  • a SIDS Initial Assessment Report (SIAR)
  • a SIDS Initial Assessment Profile (SIAP), which is a summary of SIAR, to be submitted to the OECD HPV Chemicals Programme

OECD’s SIDS Initial Assessment Meetings (SIAM) review these documents, deliver and approve SIDS with conclusions and recommendations.

The SIDS Dossiers, together with the SIDS Initial Assessment Reports, once they are agreed upon by Member countries are published by UNEP Chemicals.

The following table lists all Fluorinated Chemicals included in these programs.

The table is listed by CAS numbers, as does the OECD data base.

CAS numberChemical nameDesignationFormulaInitiativeSIAM number
75-10-5 Difluoromethane HFC-32 CH2F2 ICCA compound assessed at SIAM 18
75-37-6 1,1-difluoroethane HFC-152a CH3-CHF2 ICCA compound US EPA compound 22 (low priority)
75-38-7 1,1-difluoroethylene Vinylidene fluoride (VF2) HFC-1132a CH2=CF2 ICCA compound assessed at SIAM 13
75-45-6 Chlorodifluoromethane HCFC-22 CHClF2 EU 2nd Prioritysubstance  
75-68-3 1-chloro-1,1-difluoroethane HCFC-142b CClF2-CH3 ICCA compound assessed at SIAM 12
79-38-9 Chlorotrifluoroethylene HCFC-1113 CClF=CF2 ICCA compound assessed at SIAM 16
116-14-3 Tetrafluoroethylene HFC-1114 CF2=CF2 ICCA compound  
116-15-4 Hexafluoropropene 1,1,2,3,3,3-hexafluoroprop-1-ene HFC-216 CF3CF=CF2 OECD SIDS compound 10
306-83-2 2,2-dichloro-1,1,1-trifluoroethane HCFC-123 CHCI2-CF3 ICCA compound US EPA compound  
354-33-6 Pentafluoroethane HFC-125 CHF2-CF3 ICCA compound assessed at SIAM 20
420-46-2 1,1,1-trifluoroethane HFC-143a CH3-CF3 ICCA compound US EPA compound  
1717-00-6 1,1-dichloro-1-fluoroethane HCFC-141b CCI2F-CH3 ICCA compound assessed at SIAM 12
2551-62-4 Sulphur hexafluoride SF6 ICCA compound 22 (low priority)
2837-89-0 1-chloro-1,2,2,2-tetrafluoroethane HCFC-124 CHCIF-CF3 ICCA compound assessed at SIAM 16


ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals) publishes the Joint Assessment of Commodity Chemicals (JACC) series of reports, containing comprehensive critical reviews of toxicological and ecotoxicological data for some fluorocarbons, predominantly those having widespread and multiple uses. In some cases, these hazard assessments are further extended to enable their application in risk assessment scenarios e.g. under the EC Existing Substances Regulation (EEC) 793-93.

CAS numberChemical nameDesignationFormulaStatus
75-10-5 Difluoromethane HFC-32 CH2F2 JACC n° 32
75-37-6 1,1-difluoroethane HFC-152a CH3-CHF2 JACC n° 45
75-38-7 Vinilydene Fluoride HFC-1132a CH2=CF2 JACC n° 49
75-43-4 Dichlorofluoromethane HCFC-21 CHCl2F JACC n° 16
75-45-6 Chlorodifluoromethane HCFC-22 CHClF2 JACC n° 9
75-68-3 1-chloro-1,1-difluoroethane HCFC-142b CClF2-CH3 JACC n° 17
75-88-7 1-chloro-2,2,2-trifluoroethane HCFC-133a CH2Cl-CF3 JACC n° 14
116-14-3 Tetrafluoroethylene HFC-1114 CF2=CF2 JACC n° 42 & 42a
116-15-4 Hexafluoropropylene   CF2=CF-CF3 JACC n° 48 & 48a
306-83-2 2,2-dichloro-1,1,1-trifluoroethane HCFC-123 CHCI2-CF3 JACC n° 47
354-33-6 Pentafluoroethane HFC-125 CHF2-CF3 JACC n° 24
406-58-6 1,1,1,3,3-pentafluorobutane HFC-365mfc CF3CH2CF2CH3 JACC in preparation
420-46-2 1,1,1-trifluoroethane HFC-143a CF3-CH3 JACC n° 52
460-73-1 1,1,1,3,3- pentafluoropropane HFC-245fa CF3CH2CHF2 JACC n° 44
811-97-2 1,1,1,2-tetrafluoroethane HFC-134a CF3-CH2F JACC n° 50
1649-08-07 1,2-dichloro-1,1-difluoroethane HCFC-132b CClF2-CH2Cl JACC n° 11
1717-00-6 1,1-dichloro-1-fluoroethane HCFC-141b CCI2F-CH3 JACC n° 29
2837-89-0 1-chloro-1,2,2,2-tetrafluoroethane HCFC-124 CHCIF-CF3 JACC n° 46





If you are interested in a JACC report, please contact ECETOC
Av. E. Van Nieuwenhuyse 4, Bte. 6
B-1160 Brussels, Belgium
Tel: +32 2 675 36 00
Fax: +32 2 675 36 25