Toxicological profile HFC-43-10mee

HFC-43-10-mee (1,1,1,2,2,3,4,5,5,5-decafluoropentane)

Animal testing indicated that HFC-43-10mee is a slight skin irritant and a mild eye irritant, but is not a skin sensitizer.

Single exposure to 5,000 ppm HFC-43-10mee by inhalation caused tremors. A different single exposure study by inhalation in rats caused incoordination, hyperactivity and prostration; pathological examination of rats from this study revealed kidney and lung changes, and external hair loss. Repeated exposures to 1,900 - 3,500 ppm caused tremors or convulsions, behavioral effects, and altered clinical chemistry. These effects were temporary. In a different repeated exposure test the No-Observed-Adverse-Effect-Level (NOAEL) for convulsions was 1000 ppm. Results indicate convulsions is an acute effect of HFC-43-10mee. The 90-day No-Observed-Adverse-Effect-Level (NOAEL) is 500 ppm.

In animal testing HFC-43-10mee produced developmental effects only at exposure levels producing other toxic effects in the adult animal. No animal data are available to define the carcinogenic or reproductive hazards of HFC-43-10mee. Tests have shown that HFC-43-10mee does not cause genetic damage in bacterial or mammalian cell cultures. It has not produced genetic damage in tests on animals.

Source: Safety Data Sheet of DuPont