HFC-365mfc (1,1,1,3,3-pentafluorobutane)

Acute toxicity

Oral route, LD 50, rat
Inhalation, LC 50, 4 h, rat

> 2,000 mg/kg
> 10 %

Irritation

Rabbit, non irritant (eyes)
Rabbit, slightly irritant (eyes)

Sensitization

Guinea Pig, non sensitizing (skin)

Chronic toxicity
Inhalation, after repeated exposure, rat

Target organ : skeleton, 50,000 ppm,
observed effect

No mutagenic effect
Inhalation, after a single exposure, dog

>= 7.5 %, cardiac sensitization following adrenergic stimulation

Comments

According to these toxicological results HFC 365mfc can be considered not hazardous in normal conditions of handling and use