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| Toxicological profile HFC-236fa |
HFC-236fa (1,1,1,3,3,3-hexafluoropropane)
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Inhalation 4-hour ALC rats
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> 189,000 ppm
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Single exposure caused: Narcosis. Cardiac sensitization, a potentially fatal disturbance of heart rhythm associated with a heightened sensitivity to the action of epinephrine (NOAEL 10 %; LOAEL 15 %)
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Repeated exposure caused
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No significant toxicological effects.
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No-Observed-Adverse-Effect-Level
(NOAEL)
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20,000 ppm
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Limited studies do not suggest developmental toxicity.
Specific studies to evaluate the effect on female reproductive performance have not been conducted; however, limited information obtained from studies on developmental toxicity do not indicate adverse effects on female reproductive performance. Tests have shown that this material does not cause genetic damage in bacterial or mammalian cell cultures. No animal data are available to define the carcinogenicity of this material.
Source: Safety Data Sheet of DuPont
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