Toxicological profile HFC-152a

HFC-152a has low acute inhalation toxicity, with a rat 4-hour approximate lethal concentration of 383,000 ppm.  Laboratory animals treated with exogenous epinephrine were exposed to 50,000 or 150,000 ppm HFC-152a in a cardiac sensitisation study.  The no, and low observed adverse effects concentrations were 50,000 and 150,000 ppm, respectively.

HFC 152a was not mutagenic in the in vitro bacterial reverse mutation test (Ames test) in Salmonella typhimurium and Escherichia coli strains.  HFC 152a showed evidence of weak clastogenicity in an in vitro human lymphocyte chromosome aberration test.  Further evaluation of the chromosome aberration potential using an in vivo micronucleus test produced negative results.

HFC-152a has low repeated inhalation toxicity.

HFC-152a is not a developmental toxin in laboratory animals. The NOAEL for developmental toxicity was 50,000 ppm.

HFC-152a was not carcinogenic and did not produce life-shortening toxic effects at concentrations ranging from 2000 to 25,000 ppm..

Source: Safety Data Sheet of DuPont