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| Toxicological profile HFC-152a |
HFC-152a (1,1-difluoroethane)
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Inhalation 4-hour ALC
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383,000 ppm in rats
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Oral ALD
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>1500 mg/kg in rats
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The compound is untested for skin or eye irritancy, and for animal sensitization. Effects in animals from single, high exposure by inhalation include labored breathing, lung irritation, lethargy, incoordination, and loss of consciousness. Cardiac sensitization occurred in dogs exposed to a concentration of 150,000 ppm in air and given an intravenous epinephrine challenge. Effects of repeated exposure include increased urinary fluorides, reduced kidney weight, and reversible kidney changes. The effects of a single, high oral dose include weight loss and lethargy.
Tests in animals demonstrate no carcinogenic activity or developmental effects. Tests in animals for reproductive effects have not been performed. This compound does not produce genetic damage in bacterial cell cultures but has not been tested in animals.
Source: Safety Data Sheet of DuPont
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