Toxicological profiles of PFCs Perfluorocarbons

PFC-116 (hexafluoroethane)

Animal Data
Inhalation 4-hour LC50 : > 800,000 ppm in rats

Effects observed in animals by inhalation include decreased growth rate, pulmonary changes, irregular respiration, increased urine volume and creatinine, reversible pathological changes in the kidneys, and increased urinary fluoride concentration. One study showed no arrhythmogenic effects in dogs at a concentration of 20 %, while another study did show some arrhythmogenic effects in both guinea pigs and dogs. Long-term inhalation exposures resulted in an initial decrease in growth rate, but no other adverse changes were noted. No animal test reports are available to define carcinogenic, developmental, or reproductive hazards. The compound does not produce genetic damage in bacterail cell cultures but has not been tested in animals.

Source
Safety Data Sheet of DuPont

PFC-218 (octafluoropropane)

Acute inhalation toxicity study (rat): the 4-hour lc50 is above 110,000 ppm. these results suggest that on an acute inhalation basis the test material can be considered as a simple asphyxiant.
See the fourth summary for data of additional higher exposure levels. (Huntingdon Research Centre; mar 02, 1995; min 68/930457)

Cardiac sensitization study (dog): the test material does have some limited potential to produce cardiac sensitization at very high (greater than 30%) concentrations in air. the inhalation of such high concentration of the test material during use is considered unlikely. The effects of oxygen depletion (lack of sufficient oxygen to breathe) should become evident before the 30% level of the test material is reached.
(Huntingdon Research Centre; jun 23, 1993; min 101/930623)

Bacterial mutation assay salmonella typhimurium (strains ta 1535, ta 1537, ta 1538, ta 98 and ta 100): negative.
(Huntingdon Research Centre; aug 24, 1993; min 67/920961)

Acute inhalation toxicity 4-hour (rat): lc50 exceeds 810,000 ppm
(Huntingdon Life Sciences; may 02, 1997; 96-5308)

PFC-c318 (octafluorocyclobutane)

Animal Data

Inhalation 4-hour ALC : > 800,000 ppm in rats

Toxicity described in animals from single exposure by inhalation include nonspecific effects such as weight loss and irregular respiration. Cardiac sensitization occurred in dogs exposed to concentrations of 10-25% in air and given an epinephrine challenge. Repeated exposures to concentrations of 1-20% produced no adverse changes. The compound is not an eye irritant.

No animal test reports are available to define carcinogenic, developmental, or reproductive hazards. Tests for heritable genetic damage in insects were inconclusive. No other test reports are available to define mutagenic hazards.

Source
Safety Data Sheet of DuPont

PFC-3-1-10 (decafluorobutane)

Acute inhalation toxicity: (rat): relatively harmless.
(Huntingdon Research Centre; sep 15, 1992; min 58/920933)

Cardiac sensitization: (dog): not a cardiac sensitizer.
(Huntingdon Research Centre; dec 02, 1992; min 62b/921211)

Two-week repeat dose preliminary inhalation toxicity (ratat a target concentration of 10,000 ppm (10%), no treatment-related effects were noted for clinical signs, body weight, food consumption, water consumption, macroscopic pathology or organ weights.
(Huntingdon Research Centre; dec 14, 1992; min 60/921530)

90 day inhalation study in rats: no treatment-related effects were observed in this study in which rats were exposed to 5,000 ppm, 15,000 ppm, and 50,000 ppm of the test material for 6 hours per day, 5 days per week for a total of 13 weeks. these results indicate that the toxicity of the test material following repeated inhalation exposure is very low and suggest that the gas can be treated as a simple asphyxiant.
(Huntingdon Research Centre; jun 14, 1993; min 61/930522)

Bacterial mutation assay:. salmonella typhimurium (strains ta 1535, ta 1537, ta 1538, ta 98 and ta 100) and a tryptophan dependent mutant of esherichia coli (wp uvra): not mutagenic.
(Huntingdon Research Centre; dec 10, 1992; min 96/921385)

Chromosomal aberration test in cultured mammalian cells: non-clastogenic
(Japan Bioassay Laboratory; mar 10, 1994; 5929)

PFC-4-1-12 (perfluoropentane)

Acute oral toxicity (rat): practically non-toxic.
(Hazleton Wisconsin; mar 28, 1991; hwi 10102636)

4-week oral gavage toxicity (rats): based on the results of this study, the no observable effect level for pf-5050 in male and female rats was greater than 2,000 mg/kg.
(Hazleton Wisconsin; jan 16, 1992; hwi 6329-105)

Primary dermal irritation (rabbit): non-irritating...
(Hazleton Wisconsin; apr 04, 1991; hwi 10102637)

Primary ocular irritation (rabbit): practically non-irritating.
(Hazleton Wisconsin; apr 04, 1991; hwi 10102638)

Salmonella/mammalian-microsome reverse mutation assay: no cytotoxicity.
The product cannot be adequately tested using the salmonella mutation assay.
(Hazleton Washington; oct 22, 1991; hla 12616-0-401)

PFC-5-1-14 (perfluorohexane)

Acute oral toxicity (rat): practically non-toxic
(Hazleton Wisconsin; mar 28, 1991; hwi 10102633)

4-week oral gavage toxicity study (rats):.
Based on the results of this study, the no-observable-effect level for pf-5060 in male and female rats was greater than 2,000 mg/kg.
(Hazleton Wisconsin; feb 05, 1992; hwi 6329-102).

Primary dermal irritation (rabbit): non-irritating.
(Hazleton Wisconsin; apr 04, 1991; hwi 10102634)

Primary ocular irritation (rabbit): non-irritating.
(Hazleton Wisconsin; apr 04, 1991; hwi 10102635)

Acute inhalation: the data suggest that the 1-hour acute lc50 is greater than 5,260 milligrams per liter. the acute toxicity of the vapors is very low.
(Industrial Bio-test Laboratories, inc.; jul 19, 1976; 3m t-1497)

Sub-chronic inhalation: some differences were observed between the test Animals and controls in some blood chemistry parameters and in hematologic values (females only). All blood study results are considered to be within a biologically acceptable range. the significance of these findings is not known at this time. a review of these findings by the 3m medical department exposure guideline committee led the committee to conclude that these findings are biologically unimportant because the exposures were high and for an extended period.
(University of California at San Francisco; dec 01, 1977; 3m t-1690)

Two-week repeat dose preliminary inhalation toxicity study in rats rats were exposed to 50,000 parts per million of pf-5060 for six hours a day, five days a week for two weeks in a 750 liter exposure chamber (whole body exposure). No effects were considered to be of toxicological significance.
(Huntington Research Centre; jun 08, 1992; min 56/911538)

90-day inhalation toxicity study (rat): in summary, no significant effects were found in the 90-day inhalation toxicity study with perfluorohexane. The no adverse effect level for the study is 49,821 ppm.
(Huntington Research Centre; nov 02, 1992; min 59/920819)

Cardiac sensitization (dog): not a cardiac sensitizer.
(Huntington Research Centre; dec 02, 1992; min 62a/921210)

Salmonella/mammalian-microsome reverse mutation assay: no cytotoxicity. The product cannot be adequately tested using the salmonella mutation assay.
(Hazleton Washington; oct 22, 1991; hla 12615-0-401)