Toxicological profiles of HFC-43-10mee (1,1,1,2,2,3,4,5,5,5-decafluoropentane)

HFC-43-10mee has very low acute oral, dermal and inhalation toxicity. The oral LD50 in fasted male and female rats and the dermal ALD in rabbits is greater than 5000 mg/kg. The 4-hour inhalation LC50 in male and female rats is 11,100 ppm. Inhalation exposures of 2000 ppm and greater were associated with transient tremors, seizures and central nervous system effects..

HFC-43-10mee was not mutagenic in Salmonella typhimurium or Escherichia coli both in the presence and absence of a metabolic activation system. Additionally, in rats exposed 6 hours a day for 2 consecutive days to 2000, 3500, or 7000 ppm of HFC-43-10mee, no increase in micronuclei was noted in their bone-marrow cells. HFC-43-10mee was not clastogenic when evaluated in human lymphocytes in vitro both in the presence and absence of a metabolic activation system

HFC-43-10mee has low repeated inhalation toxicity. Effects observed in a 90-day study were generally the same as the central nervous system effects observed in acute inhalation study.

HFC-43-10mee is not a developmental toxin in laboratory animals.

Source
Safety Data Sheet of DuPont