Toxicological profiles of HFC-365mfc (1,1,1,3,3-pentafluorobutane)

Acute toxicity
Oral route, LD 50, rat Inhalation, LC 50, 4 h, rat
> 2,000 mg/kg > 10 %
Irritation Rabbit, non irritant (eyes)
Rabbit, slightly irritant (eyes)
Sensitization Guinea Pig, non sensitizing (skin)
Chronic toxicity
Inhalation, after repeated exposure, rat
Target organ : skeleton, 50,000 ppm, observed effect
No mutagenic effect
Inhalation, after a single exposure, dog
>= 7.5 %, cardiac sensitization following adrenergic stimulation
Comments According to these toxicological results HFC 365mfc can be considered not hazardous in normal conditions of handling and use

Source
Safety Data Sheet of Solvay