HFCs & Occupational Health

HFC-23 (trifluoromethane)

PEL (OSHA) : None established
TLV (ACGIH) : None established
AEL * : 1000 ppm, 8 & 12 Hr. TWA

Source
Safety Data Sheet of DuPont

* AEL is DuPont's Acceptable Exposure Limit

HFC-32 (difluoromethane)

The acute toxicity of difluoromethane is very low, the 4-hr LC50 being greater than 52% in air (3). Also, it is not mutagenic in vitro (9-11) or in vivo(12). In studies of its potential to cause sensitization of the heart to adrenaline in dogs, an exposure level of 350,000 ppm (35%) did not cause a response (4). Exposures at levels up to 50,000 ppm, the highest level tested, did not cause toxicity in rats in 4 - and 13- week studies, nor did it cause developmental effects in rats (7) or rabbits (8).

It is, therefore, recommended that an exposure level associated with good industrial hygiene practice be established for this material as has been done with CFC-11, CFC-12, HFC-134a, and HFC-125. Typically, this level has been 1000 ppm as a time-weighted average (TWA) for an 8-hr day.

8-hr TWA : 1000 ppm (2200 mg/m3)

Source
Workplace Environmental Exposure Level Guides
AIHA, 1999

HFC 125 (pentafluoroethane)

An occupational exposure limit (8-hour time weighted average) of 1,000 ppm (4,910 mg/m3) is recommended by producers.

Source
Joint Assessment of Commodity Chemicals No. 24
HFC 125 (Pentafluoroethane)
ECETOC May 1994

HFC-134a (1,1,1,2-tetrafluoroethane)

An occupational exposure limit (8 h average) of 1,000 ppm (4,250 mg/m3) is recommended by AIHA.

Source
Joint Assessment of Commodity Chemicals No. 31
HFC-134a (1,1,1,2-tetrafluoroethane)
ECETOC, February 1995

HFC-143a (1,1,1-trifluoroethane)

Authorized limit values 1,1,1-trifluoroethane
SAEL (Solvay) 1990-2000
TWA = 500 ppm

Source
Safety Data Sheet of Solvay

HFC-152a (1,1-difluoroethane)

Exposure limits HFC-152a

PEL (OSHA) : None established
TLV (ACGIH) : None established
AEL * (DuPont) : 1000 ppm, 8 Hr. TWA
WEEL (AIHA) : 1000 ppm, 8 Hr. TWA

Source
Safety Data Sheet of DuPont

* AEL is DuPont's Acceptable Exposure Limit

HFC-227ea (1,1,1,2,3,3,3-heptafluoropropane)

Authorized limit value : 1,1,1,2,3,3,3-heptafluoropropane
SAEL (Solvay) 2000-2001
TWA = 1,000 ppm

Source
Safety Data Sheet of Solvay

HFC-236fa (1,1,1,3,3,3-hexafluoropropane)

PEL (OSHA) : None established
TLV (ACGIH) : None established
AEL * (DuPont) : 1000 ppm, 8 & 12 Hr. TWA
WEEL (AIHA) : 1000 ppm, 8 Hr. TWA

Source
Safety Data Sheet of DuPont

* AEL is DuPont's Acceptable Exposure Limit

HFC-245fa (1,1,1,3,3-pentafluoropropane)

Additional exposure limits : AIHA WEEL TWA (8 hrs) = 300 ppm

Source
Safety Data Sheet of Great Lakes Chemical Corporation

HFC-365mfc (1,1,1,3,3-pentafluorobutane)

Respiratory protection
Minimum need if the local exhaust ventilation is adequate.
Self-contained breathing apparatus in medium confinement/insufficient oxygen/in case of large uncontrolled emissions/in all circumstances when the mask and cartridge do not give adequate protection.
Use only respiratory protection that conforms to international/national standards.

Hand protection
Protective gloves - chemical resistant: Recommended materials: Neoprene

Eye protection
Wear protective goggles for all industrial operations.

Skin protection
Overalls
Apron/boots of butyl rubber if risk of splashing.

Other precautions
Shower and eye wash stations.
Consult the industrial hygienist or the safety manager for the selection of personal protective equipment suitable for the working conditions.
Do not smoke, eat and drink in the working area.

Source
Safety Data Sheet of Solvay

HFC-43-10-mee (1,1,1,2,2,3,4,5,5,5-decafluoropentane)

Exposure guidelines

PEL (OSHA) : none established
TLV (ACGIH) : none established
AEL * (DuPont) : 200 ppm, 8 and 12 h TWA
400 ppm, Ceiling

Source
Safety Data Sheet of DuPont

* AEL is DuPont's Acceptable Exposure Limit. Where governmentally imposed occupational exposure limits which are lower than the AEL are in effect, such limits shall take precedence.